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A short efficient synthesis of (S)-4-amino-5-hexenoic acid [(S)-vigabatrin]

โœ Scribed by Wei, Zhong Yong; Knaus, Edward E.


Book ID
120085058
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
324 KB
Volume
58
Category
Article
ISSN
0022-3263

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A short synthesis of 5-amino[4-14]laevul
โœ J B Cambell; J S Johnston ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 219 KB

## 5-Amin0[4-'~C]laevulinic acid hydrochloride has been prepared from potassium [14C]cyanide in 56% overall yield. The key step is the palladium[O] catalysed coupling of 2-phthalimid0[l-'~C]acetyl chloride with 2-carboethoxyethylzinc iodide to give 5-phthalimid0[4-'~C]laevulinic acid ethyl ester i