This report describes the synth i s of arbaprostil, I cytoprotective antiulcer a ent, an a group of relate 15-methyl rostaglandins, la%eled w I tritium at the C-1 position, [om 15(R)-and 1 S(S)-15-methylprostaglandin. D2 methyl esters. Radiolytic decomposition of the labeled product and some interme
A route to tritium labelled 11-methyl prostaglandins
β Scribed by Richard R. Muccino; Joseph Cupano; Arnold A. Liebman
- Book ID
- 119049072
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 512 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0090-6980
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π SIMILAR VOLUMES
## s rnDk1ARY The complete chemical synthesis of unsaturated precursors of eicosanoids of series 1,2,3 is described. Selective hydrogenation by gaseous tritium of eicosapolyenoic acid acetylenic analogues was used to introduce the label into dihomo-r-linolenic, arachidonic and timnodonic acids, fr
## Abstract The oneβstage enzymatic synthesis of tritiumβlabelled prostaglandin D~2~ from labelled arachidonic acid was performed by using the enzyme system PGHβsynthetase/PGHβPGDβisomerase. By enzymatic and chemical transformation of [^3^H]PGD~2~ the following compounds were obtained: 15βketoβ13,1
+)-(9,11)-Epithia-(11,12)-methano-thromboxane A2, which