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A practical process for large-scale synthesis of (S)-5-hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid (5-HETE)

โœ Scribed by E.J. Corey; Shun-ichi Hashimoto


Book ID
107858304
Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
233 KB
Volume
22
Category
Article
ISSN
0040-4039

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A stereoselective and practical synthesi
โœ E.J. Corey; Mukund M. Mehrotra ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 267 KB

A stereoselective synthesis of 4, a possible biosynthetic precursor of lipoxins, is reported. A pathway is suggested by which 4 can give rise to the biologically active lipoxins 1 and 2. In 1984 Serhan, Hamberg and Samuelsson reported that human leukocytes convert 15(S)-