A stereoselective and practical synthesis of 5,6(S,S)-epoxy-15(S)-hydroxy-7(E),9(E),11(Z),13(E)-eicosatetraenoic acid (4), possible precursor of the lipoxins

✍ Scribed by E.J. Corey; Mukund M. Mehrotra

• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 267 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)85161-8

✦ Synopsis

A stereoselective synthesis of 4, a possible biosynthetic precursor of lipoxins, is reported. A pathway is suggested by which 4 can give rise to the biologically active lipoxins 1 and 2.

In 1984 Serhan, Hamberg and Samuelsson reported that human leukocytes convert 15(S)-