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A Practical Procedure for Reduction of Primary, Secondary and Tertiary Amides to Amines

โœ Scribed by Reeves, Jonathan T.; Tan, Zhulin; Marsini, Maurice A.; Han, Zhengxu S.; Xu, Yibo; Reeves, Diana C.; Lee, Heewon; Lu, Bruce Z.; Senanayake, Chris H.


Book ID
118231556
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
207 KB
Volume
355
Category
Article
ISSN
1615-4150

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๐Ÿ“œ SIMILAR VOLUMES


Selective reduction of secondary amides
โœ Byung H. Lee; Michael F. Clothier ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 89 KB

Secondary amides activated with a Cbz group can be reduced to their corresponding hemiaminals using lithium borohydride. Hydrogenation then removes the Cbz and hydroxyl groups to produce the related amine. Tertiary amides are not affected.

ChemInform Abstract: Selective Reduction
โœ Byung H. Lee; Michael F. Clothier ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 28 KB ๐Ÿ‘ 2 views

Selective Reduction of Secondary Amides to Amines in the Presence of Tertiary Amides. -The transformation is achieved by reduction of secondary amide moieties bearing an activating Cbz group with hydrides. Catalytic hydrogenation of the resulting hemiacetals removes the hydroxyl and the Cbz group t

A new method for the reduction of second
โœ Richard F. Borch ๐Ÿ“‚ Article ๐Ÿ“… 1968 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 200 KB

The reduction of amides with lithium aluminum hydride, aluminum hydride, lithium trimethoxyaluminum hydride, and diborane to the corresponding amines is well known (1).