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A new method for the reduction of secondary and tertiary amides

โœ Scribed by Richard F. Borch


Publisher
Elsevier Science
Year
1968
Tongue
French
Weight
200 KB
Volume
9
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


The reduction of amides with lithium aluminum hydride, aluminum hydride, lithium trimethoxyaluminum hydride, and diborane to the corresponding amines is well known (1).


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Secondary amides activated with a Cbz group can be reduced to their corresponding hemiaminals using lithium borohydride. Hydrogenation then removes the Cbz and hydroxyl groups to produce the related amine. Tertiary amides are not affected.

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