A new method for the reduction of secondary and tertiary amides
โ Scribed by Richard F. Borch
- Publisher
- Elsevier Science
- Year
- 1968
- Tongue
- French
- Weight
- 200 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The reduction of amides with lithium aluminum hydride, aluminum hydride, lithium trimethoxyaluminum hydride, and diborane to the corresponding amines is well known (1).
๐ SIMILAR VOLUMES
Secondary amides activated with a Cbz group can be reduced to their corresponding hemiaminals using lithium borohydride. Hydrogenation then removes the Cbz and hydroxyl groups to produce the related amine. Tertiary amides are not affected.
1998 amide formation, amide hydrolysis amide formation, amide hydrolysis O 0320 23 -069 A New Mild Method for the Cleavage of the Amide Bond: Conversion of Secondary and Tertiary Amides to Esters. -A variety of secondary and tertiary amides (I) (21 examples) is efficiently converted to the correspon
Selective Reduction of Secondary Amides to Amines in the Presence of Tertiary Amides. -The transformation is achieved by reduction of secondary amide moieties bearing an activating Cbz group with hydrides. Catalytic hydrogenation of the resulting hemiacetals removes the hydroxyl and the Cbz group t