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ChemInform Abstract: A New Mild Method for the Cleavage of the Amide Bond: Conversion of Secondary and Tertiary Amides to Esters.

✍ Scribed by A. B. CHARETTE; P. CHUA

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

1998 amide formation, amide hydrolysis amide formation, amide hydrolysis O 0320 23 -069 A New Mild Method for the Cleavage of the Amide Bond: Conversion of Secondary and Tertiary Amides to Esters. -A variety of secondary and tertiary amides (I) (21 examples) is efficiently converted to the corresponding esters (III) by a novel one-pot procedure. The amides are activated with triflic anhydride to mixed iminium anhydrides which are cleaved by ethanol. -(CHARETTE, A.

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ChemInform Abstract: Mild Method for the
ChemInform Abstract: Mild Method for the Synthesis of Thiazolines from Secondary and Tertiary Amides.
✍ A. B. CHARETTE; P. CHUA πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 31 KB πŸ‘ 1 views

Mild Method for the Synthesis of Thiazolines from Secondary and Tertiary Amides. -Base-promoted treatment of amides [cf. (I)] with triflic anhydride generates an iminium or imino triflate which reacts with an aminothiol directly to biologically interesting thiazolines. When optically pure cysteine