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A potentially functional polymorphism in the promoter region of let-7 family is associated with survival of hepatocellular carcinoma

✍ Scribed by Xie, Kaipeng; Liu, Jibin; Zhu, Liguo; Liu, Yao; Pan, Yun; Wen, Juan; Ma, Hongxia; Zhai, Xiangjun; Hu, Zhibin

Book ID
123262231
Publisher
Elsevier
Year
2013
Tongue
English
Weight
233 KB
Volume
37
Category
Article
ISSN
1877-7821

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## Abstract The miR‐34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR‐34 function can impair p53‐mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of __pri‐miR‐34b/c__ (423 bp from th