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A potentially functional polymorphism in the regulatory region of let-7a-2 is associated with an increased risk for diabetic nephropathy

✍ Scribed by Zhou, Ji; Peng, Rui; Li, Tianju; Luo, Xiaomei; Peng, Huimin; Zha, He; Yin, Pin; Wen, Li; Zhang, Zheng


Book ID
122083344
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
561 KB
Volume
527
Category
Article
ISSN
0378-1119

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## Abstract The miR‐34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR‐34 function can impair p53‐mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of __pri‐miR‐34b/c__ (423 bp from th