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A functional polymorphism C-1310G in the promoter region of Ku70/XRCC6 is associated with risk of renal cell carcinoma

✍ Scribed by Wei Wang; Xuping Pan; Xinying Huo; Fu Yan; Meilin Wang; Dingxian Wang; Yanqin Gao; Qiang Cao; Dewei Luo; Chao Qin; Changjun Yin; Zhengdong Zhang


Book ID
112142424
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
117 KB
Volume
51
Category
Article
ISSN
0899-1987

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✍ Yan Xu; Li Liu; Jibin Liu; Yixin Zhang; Jian Zhu; Jianguo Chen; Sheng Liu; Zheng πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 French βš– 183 KB πŸ‘ 2 views

## Abstract The miR‐34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR‐34 function can impair p53‐mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of __pri‐miR‐34b/c__ (423 bp from th