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A novel functional polymorphism in the Cdc6 promoter is associated with the risk for hepatocellular carcinoma

✍ Scribed by Xing-Dong Xiong; Jian-Hong Fang; Fu-En Qiu; Jing Zhao; Jiasen Cheng; Yunfei Yuan; Sheng-Ping Li; Shi-Mei Zhuang

Book ID
113809182
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
352 KB
Volume
643
Category
Article
ISSN
0027-5107

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## Abstract The miR‐34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR‐34 function can impair p53‐mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of __pri‐miR‐34b/c__ (423 bp from th