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A Functional Polymorphism in the Epidermal Growth Factor Gene Is Associated With Risk for Hepatocellular Carcinoma

✍ Scribed by Barham K. Abu Dayyeh; May Yang; Bryan C. Fuchs; Daniel L. Karl; Suguru Yamada; John J. Sninsky; Thomas R. O'Brien; Jules L. Dienstag; Kenneth K. Tanabe; Raymond T. Chung

Book ID: 119979745
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 537 KB
Volume: 141
Category: Article
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2011.03.045

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## Abstract The miR‐34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR‐34 function can impair p53‐mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of __pri‐miR‐34b/c__ (423 bp from th