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A polymorphism in the angiogenesis inhibitor, endostatin, in sporadic colorectal adenocarcinoma

✍ Scribed by Helvia Nascimento; Claudio Saddy Rodrigues Coy; Juvenal Ricardo Navarro Góes; Fernando Ferreira Costa; Carmen Silvia Passos Lima


Book ID
106058877
Publisher
Springer
Year
2004
Tongue
English
Weight
131 KB
Volume
19
Category
Article
ISSN
0179-1958

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## Abstract Endostatin inhibits endothelial cell proliferation and migration, prerequisites of angiogenesis. A functional missense mutation (__D104N__) in endostatin was associated with an increased prostate cancer risk in a small study. We undertook a larger, prospective study within the Physician