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A polymorphism in the angiogenesis inhibitor, endostatin, in lung cancer susceptibility

✍ Scribed by Zambon, Lair; Honma, Helen N.; Lourenço, Gustavo J.; Saad, Ivete A.B.; Mussi, Ricardo K.; Lima, Carmen S.P.

Book ID
119319806
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
96 KB
Volume
59
Category
Article
ISSN
0169-5002

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## Abstract Endostatin inhibits endothelial cell proliferation and migration, prerequisites of angiogenesis. A functional missense mutation (__D104N__) in endostatin was associated with an increased prostate cancer risk in a small study. We undertook a larger, prospective study within the Physician