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A physiological pharmacokinetic model for morphine disposition in the pregnant rat

✍ Scribed by Johan L. Gabrielsson; Lennart K. Paalzow

Book ID
112473439
Publisher
Springer
Year
1983
Tongue
English
Weight
911 KB
Volume
11
Category
Article
ISSN
1573-8744

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Disposition of p-phenylbenzoic acid (PPBA) in the pregnant Wistar rat (for both mother and fetuses) was predicted by using a physiologically based pharmacokinetic model. This model was constructed from ten organs for the mother and eight organs for fetuses, with fetal blood flow based on anatomical