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Development of a Physiologically Based Pharmacokinetic Model of 2-Methoxyethanol and 2-Methoxyacetic Acid Disposition in Pregnant Rats

✍ Scribed by Sean M. Hays; Barbara A. Elswick; Gregory M. Blumenthal; Frank Welsch; Rory B. Conolly; Michael L. Gargas


Book ID
112267035
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
86 KB
Volume
163
Category
Article
ISSN
0041-008X

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✍ Masami Kawahara; Toshio Nanbo; Akira Tsuji πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 224 KB πŸ‘ 2 views

Disposition of p-phenylbenzoic acid (PPBA) in the pregnant Wistar rat (for both mother and fetuses) was predicted by using a physiologically based pharmacokinetic model. This model was constructed from ten organs for the mother and eight organs for fetuses, with fetal blood flow based on anatomical