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A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat

✍ Scribed by Johan L. Gabrielsson; Lennart K. Paalzow; Lars Nordström


Book ID
112472339
Publisher
Springer
Year
1984
Tongue
English
Weight
766 KB
Volume
12
Category
Article
ISSN
1573-8744

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Disposition of p-phenylbenzoic acid (PPBA) in the pregnant Wistar rat (for both mother and fetuses) was predicted by using a physiologically based pharmacokinetic model. This model was constructed from ten organs for the mother and eight organs for fetuses, with fetal blood flow based on anatomical