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A Photolabile Linker for the Solid-Phase Synthesis of Peptide Hydrazides and Heterocycles

✍ Scribed by Qvortrup, Katrine; Komnatnyy, Vitaly V.; Nielsen, Thomas E.

Book ID
126467946
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
591 KB
Volume
16
Category
Article
ISSN
1523-7060

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πŸ“œ SIMILAR VOLUMES

A photolabile β€˜traceless’ linker for sol
A photolabile β€˜traceless’ linker for solid-phase organic synthesis
✍ James R Horton; Louise M Stamp; Anne Routledge πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 75 KB

A photolabile linker based on a thiohydroxamic acid has been shown to be an efficient 'traceless' linker, revealing an aliphatic CH bond on photolysis at 350 nm. Methods for the synthesis, loading and photolytic cleavage of the linker are described.