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Design of a versatile linker for solid phase peptide synthesis: Synthesis of C-terminal primary/seconary amides and hydrazides
β Scribed by R. Ramage; S.L. Irving; C. McInnes
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 272 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(t) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off th
A new linker based on the dibenzosuberyl system was developed in order to synthesisΒ’ peptide Cterminal semicarbazones which can bΒ’ readily converted into peptide (7-terminal aldehydes. The method uses Fmoc-methodoiogy and proceeds with no loss of stereochemical integrity.