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A photochemically based synthesis of the benzannelated analog of the CC-1065 A-unit

โœ Scribed by Drost, Kevin J.; Cava, Michael P.


Book ID
118265746
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
806 KB
Volume
56
Category
Article
ISSN
0022-3263

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Adozelesin, a selected lead among cyclop
โœ Li H. Li; Robert C. Kelly; Martha A. Warpehoski; J. Patrick McGovren; Ilse Gebha ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer US ๐ŸŒ English โš– 854 KB

Adozelesin (U-73975) is a potent synthetic cyclopropylpyrroloindole (CPI) analog of the cytotoxic DNAbinding antibiotic, CC-1065. In contrast to the natural product, adozelesin and related CPI analogs do not cause delayed death in non-tumored mice. Adozelesin, selected from a series of analogs for i