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A new approach to the synthesis of the CC-1065/duocarmycin pharmacophore

✍ Scribed by Tidwell, Jeffrey H.; Buchwald, Stephen L.


Book ID
120024075
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
359 KB
Volume
57
Category
Article
ISSN
0022-3263

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ChemInform Abstract: Enzymatic Preparati
✍ R. CHENEVERT; G. COURCHESNE πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 31 KB πŸ‘ 2 views

Enzymatic Preparation of an Optically Active Precursor of the CC-1065/ Duocarmycin Pharmacophore. -Both enantiomers of the monoacetate (III) are synthesized via enzymatic desymmetrization of propanediol (I). Incorporation of these optically active monoacetates into the established synthetic routes