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ChemInform Abstract: Enzymatic Preparation of an Optically Active Precursor of the CC-1065/ Duocarmycin Pharmacophore.

✍ Scribed by R. CHENEVERT; G. COURCHESNE

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199726264

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✦ Synopsis

Enzymatic Preparation of an Optically Active Precursor of the CC-1065/ Duocarmycin Pharmacophore.

-Both enantiomers of the monoacetate (III) are synthesized via enzymatic desymmetrization of propanediol (I). Incorporation of these optically active monoacetates into the established synthetic routes provides access to both enantiomers of the common pharmacophore of CC-1065/duocarmycin (cf. (IX)).

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