Anticancer Agents, 19[1]. Synthesis of the Reduced A-Unit (CI) of the Antitumor Antibiotic CC-1065

Studies on the antitumor agent CC-1065 :

Studies on the antitumor agent CC-1065 : 1-Phenylsulfonyl-1,3-butadiene. An electrophilic equivalent to 1,3-butadiene for the synthesis of 3,31-bipyrroles.

✍ Serge Halazy; Philip Magnus 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 184 KB

Sequential conjugate additions of methyl, TOSMIC anion and TOSMIC anion to I-pkenyZsuZfonyZ-1,3-butadiene provides a direct route to 3,3l-bipyrroles, andillustrates that I-pkenylsuZfonyZ-1,3-butadiene can functionas an electropkilic 1,3-butadiene equivalent. Recently we reported the synthesis of th