A phase II study of high-dose cytosine arabinoside in the treatment of acute leukaemia in adults
โ Scribed by Michael J. Barnett; Ama Z. S. Rohatiner; Trivadi S. Ganesan; Michael A. Richards; Ann Miller; T. Andrew Lister
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 325 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0344-5704
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High-dose cytosine arabinoside (Ara-C) was used in adult patients with refractory acute nonlymphoblastic leukemia, either alone (3 g/m2 every 12 h X 12 doses) or with 3 additional days of anthracycline antibiotics. The systemic toxicities were similar for both groups without an increase in the group
Effective treatment of the elderly patients (265 years) with acute nonlymphocytic leukemia (ANLL) remains elusive and controversial. In the present study, single-agent Cytosine Arabinoside (AM-C) was administered at an intermediate dose level (500 mg/m2 intravenously [I.V.] I-hour infusion q12 hours