𝔖 Bobbio Scriptorium
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A pharmacokinetic model for high-dose methotrexate infusions in man

✍ Scribed by Steven D. Reich; Nicholas R. Bachur; Robert H. Goebel; Mones Berman

Book ID
112473379
Publisher
Springer
Year
1977
Tongue
English
Weight
666 KB
Volume
5
Category
Article
ISSN
1573-8744

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A pharmacokinetic study was performed in plasma and cerebrospinal fluid (CSF) of patients suffering from brain tumors to describe the disposition of methotrexate. An open three-compartment model was developed to fit together the data obtained in plasma and CSF. The pharmacokinetic parameters obtaine