High dose methotrexate (HDMTX) pharmacokinetic profile in osteosarcoma patients
β Scribed by Comandone, A.; Boglione, A.; Bacci, G.; Oliva, C.; Bergnolo, P.; Leone, L.; Ferrari, S.; Bumma, C.
- Book ID
- 122740689
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 255 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0959-8049
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## Abstract ## BACKGROUND Highβdose methotrexate (HDMTX) is used frequently in combination regimens that include nephrotoxic chemotherapy. The authors evaluated the impact of factors such as age and prior nephrotoxic agents on MTX pharmacokinetics in children and young adults with osteosarcoma and
The authors thank Dr. James Balow at the National Institute of Diabetes, and Digestive, and Kidney Disorders for helpful suggestions during the preparation of this article. This article is dedicated to the memory of Dr. Charles Pratt, who devoted his extraordinary career to the treatment of children