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High-dose methotrexate treatment and liver function in patients with osteosarcoma

✍ Scribed by A. FABBRI; E. MOTTA; S. FERRARI; C. LONGHI; E. MARCHI; G. BACCI; E. FIGUS; G. MARCHESINI MD

Book ID
114742770
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
461 KB
Volume
236
Category
Article
ISSN
0954-6820

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## Abstract Plasma methotrexate (MTX) concentrations were quantitated in 34 patients after 127 high‐dose (35–350 mg/kg) infusions with citrovorum factor rescue. Significant linear correlations have been obtained between methotrexate dosage and concentrations in plasma at 6 and 24 hours after the in