Renal clearance of methotrexate in man during high-dose oral and intravenous infusion therapy
β Scribed by N. Christophidis; W. J. Louis; I. Lucas; W. Moon; F. J. E. Vajda
- Book ID
- 112285905
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 461 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
## Abstract Plasma methotrexate (MTX) concentrations were quantitated in 34 patients after 127 highβdose (35β350 mg/kg) infusions with citrovorum factor rescue. Significant linear correlations have been obtained between methotrexate dosage and concentrations in plasma at 6 and 24 hours after the in
A pharmacokinetic study was performed in plasma and cerebrospinal fluid (CSF) of patients suffering from brain tumors to describe the disposition of methotrexate. An open three-compartment model was developed to fit together the data obtained in plasma and CSF. The pharmacokinetic parameters obtaine