From the synthesis standpoint, there is renewed interest in the Barbier reaction (I), i.e. condensation between a reagent, A, and a halogenated derivative, RX, in the presence of a metal (magnesium or lithium), M, 1-5 due to the very high yields observed in certain cases. Furthermore, the differenc
β¦ LIBER β¦
A one-step alternative to the Grignard reaction
β Scribed by Pearce, P. J.; Richards, D. H.; Scilly, N. F.
- Book ID
- 111898897
- Publisher
- Royal Society of Chemistry
- Year
- 1972
- Weight
- 849 KB
- Volume
- 0
- Category
- Article
- ISSN
- 1472-7781
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## Abstract The reactivity in the normal Grignard addition reaction is greatly reduced when the ketone is branched in the Ξ±βposition. Alkylation in Ξ²βposition has only slight effect and in the Ξ³βposition there is no effect at all.
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