The barbier reaction: No organometallic pathway in a one-step alternative grignard reaction.

✍ Scribed by Pierre Bauer; Gérard Molle

• Publisher: Elsevier Science
• Year: 1978
• Tongue: French
• Weight: 194 KB
• Volume: 19
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)85751-8

✦ Synopsis

From the synthesis standpoint, there is renewed interest in the Barbier reaction (I), i.e. condensation between a reagent, A, and a halogenated derivative, RX, in the presence of a metal (magnesium or lithium), M, 1-5 due to the very high yields observed in certain cases.

Furthermore, the difference in yields between this reaction and the Grignard reaction (II) calls for re-examination of the reaction mechanisms in question.