✦ LIBER ✦

A novel route for solid phase synthesis of polynucleotides using phosphite chemistry

✍ Scribed by Tin M. Cao; Scott E. Bingham; Michael T. Sung

Publisher: Elsevier Science
Year: 1983
Tongue: French
Weight: 143 KB
Volume: 24
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)81591-9

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✦ Synopsis

A new route leading to a simple and rapid procedure employing Methyl Phosphoroditetrazolide (MPDT) as condensing agent for polynucleotide synthesis is described.

The phosphite triester procedure, introduced by Letsinger (l), has proven to be a general procedure for the synthesis of oligonucleotides (2-S) by the solid phase technique. Alkyl phosphorodichloridites react with a small excess of a 5'-O-protected nucleoside at -78"C to

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