A novel rearrangement of 3-cyanopyrazolo[1,5-a]pyrimidine to a pyrazolo[3,4-d]pyrimidine
โ Scribed by Thomas Novinson; Roland K. Robins; Darrell E. O'Brien
- Book ID
- 112123054
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1973
- Tongue
- English
- Weight
- 55 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0022-152X
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๐ SIMILAR VOLUMES
Derivatives of the new ring system pyrazolo [3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate
## Abstract Pyrazoloโ[3,4โ__d__]pyrimidineโ4,6โdiones **5** and pyrazolo[4,3โ__d__]pyrimidineโ5,7โdiones **7** were synthesized by Curtius rearrangement of pyrazolic monoโesters **2** and **3** followed by heteroโcyclization __via__ the ureas derivatives **4** and **6** under alkaline conditions.