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Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement

✍ Scribed by Antonino Lauria; Ilenia Abbate; Chiara Patella; Noemi Gambino; Arturo Silvestri; Giampaolo Barone; Anna Maria Almerico

Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
300 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

Derivatives of the new ring system pyrazolo [3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.

πŸ“œ SIMILAR VOLUMES

Pyrrolo[3,4-e][1,2,3]triazolo[1,5-a]pyri
Pyrrolo[3,4-e][1,2,3]triazolo[1,5-a]pyrimidine and pyrrolo[3,4-d] [1,2,3]triazolo[1,5-a]pyrimidine. New tricyclic ring systems of biological interest
✍ Antonino Lauria; Patrizia Diana; Paola Barraja; Anna Maria Almerico; Girolamo Ci πŸ“‚ Article πŸ“… 2000 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 301 KB πŸ‘ 1 views

## Abstract Derivatives of the new ring system pyrrolo[3,4‐__e__][1,2,3] triazolo[1,5‐__a__]pyrimidine **6** were prepared in high yields in one step by reaction of 3‐azidopyrrole **3** and substituted acetonitriles. Compound **6b** rearranged, upon heating in dimethyl sulfoxide in the presence of