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A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents

✍ Scribed by Wang, Xu; Pan, Ying-ming; Huang, Xiao-chao; Mao, Zhong-yuan; Wang, Heng-shan

Book ID
127006377
Publisher
Royal Society of Chemistry
Year
2014
Tongue
English
Weight
409 KB
Volume
12
Category
Article
ISSN
1477-0520

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The simple anthracycline analogues 3a-e were synthesized as potential anticancer agents. Anodic oxidation of the phenol derivative 4, phthalide anion annelation ofp-quinone monoacetals 5 and selective attachment of the side chain were the three key steps towards these target compounds.