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Synthesis of novel pyrazole and dihydropyrazoles derivatives as potential anti-inflammatory and analgesic agents

✍ Scribed by Gawad, Nagwa M. Abd-El; Georgey, Hanan H.; Ibrahim, Nashwa A.; Amin, Noha H.; Abdelsalam, Rania M.

Book ID
113100942
Publisher
Springer
Year
2012
Tongue
English
Weight
721 KB
Volume
35
Category
Article
ISSN
0253-6269

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## Abstract A series of new 3‐(substituted) 3‐hydroxy‐propanoic acid ethyl esters **1a–c**, hydrazides **2a–c**, thiosemicarbazides **3a–f**, and semicarbazides **3g**, **3h** has been synthesized. Cyclization of compounds **3a–d** in basic medium yielded 1,2,4‐triazole‐5‐thiones **4a–d**. On the o