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Synthesis of Novel 1-Pyrazolylpyridin-2-ones as Potential Anti-Inflammatory and Analgesic Agents

✍ Scribed by Magda M. F. Ismail; Yousry A. Ammar; Heba S. A. El-Zahaby; Sally I. Eisa; Saber El-Sayed Barakat

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
719 KB
Volume
340
Category
Article
ISSN
0365-6233

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## Abstract A series of new 3‐(substituted) 3‐hydroxy‐propanoic acid ethyl esters **1a–c**, hydrazides **2a–c**, thiosemicarbazides **3a–f**, and semicarbazides **3g**, **3h** has been synthesized. Cyclization of compounds **3a–d** in basic medium yielded 1,2,4‐triazole‐5‐thiones **4a–d**. On the o