A novel method for stereoselective synthesis of β-trifluoromethylated homoallylic alcohols in water
✍ Scribed by Teck-Peng Loh; Xu-Ran Li
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 202 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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1,1-Trifluoro-4-bromobut-2-ene / Aldehydes / Tin / Indium / Water The indium-mediated allylation reaction of aldehydes with 4-high regio-and excellent diastereoselectivities were obtained. bromo-1,1,1-trifluoro-2-butene in water afforded β-trifluoromethylated homoallylic alcohols in high yields. In
A simple and practical preparation of a-trifluoromethylated alcohols in water v/a indium-mediated allylation reaction and tin-mediated indium trichloride-promoted ailylation reaction of trifluoroacetaldehyde hydrate and its ethyl hcmiacetal is described in this paper.