Tin- and Indium-Mediated Allylation Reactions in Water: Highly Stereoselective Synthesis of β-Trifluoromethylated Homoallylic Alcohols

✍ Scribed by Teck-Peng Loh; Xu-Ran Li

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 249 KB
• Volume: 1999
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/(sici)1099-0690(199908)1999:8<1893::aid-ejoc1893>3.0.co;2-3

✦ Synopsis

1,1-Trifluoro-4-bromobut-2-ene / Aldehydes / Tin / Indium / Water

The indium-mediated allylation reaction of aldehydes with 4-high regio-and excellent diastereoselectivities were obtained. bromo-1,1,1-trifluoro-2-butene in water afforded β-trifluoromethylated homoallylic alcohols in high yields. In most cases,