A four-dimensional orthogonal protecting scheme that involves the acid-labile BAL linker in conjunction with Fmoc, Alloc and pNb protecting groups, which can be removed by b-elimination, allyl transfer, and reductive hydrolysis, respectively, allows the solid-phase preparation of scaffolds based on
✦ LIBER ✦
A novel, convenient, three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides
✍ Scribed by Steven A. Kates; Nuria A. Solé; Charles R. Johnson; Derek Hudson; George Barany; Fernando Albericio
- Book ID
- 103406285
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 278 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
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