✦ LIBER ✦
Four-dimensional orthogonal solid-phase synthesis of new scaffolds based on cyclic tetra-β-peptides
✍ Scribed by Miriam Royo; Josep Farrera-Sinfreu; Laia Solé; Fernando Albericio
- Book ID
- 104250627
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 178 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
A four-dimensional orthogonal protecting scheme that involves the acid-labile BAL linker in conjunction with Fmoc, Alloc and pNb protecting groups, which can be removed by b-elimination, allyl transfer, and reductive hydrolysis, respectively, allows the solid-phase preparation of scaffolds based on a cyclic tetra-b-peptide with free amino side chains ready for further elaboration.