Treatment of 7C-(2,2.3-trihaloalkylideneamino)cephalosporins with excess methanol in the presence of acid scavenger gave 7p-(2-haloalk-2-enylideneamino)-7+methoxycephalosporins.
A new synthetic route to perfluoroalkylidene-α,ω-bisphosphonates
✍ Scribed by Haridasan K. Nair; Donald J. Burton
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 172 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Starting from ethyl 2‐cyclohexen‐1‐carboxylate (**3**) the total synthesis of the perhydrohistrionicotoxin intermediate **23** was achieved in 25% overall‐yield. The two key steps involve a positionally specific addition of HOBr to the oxime‐olefin **7** and the alkylation of bromooxime
The first total synthesis of (+)-perhydrohistrionicotoxin (I), a useful neurotoxin, 1 was recently reported from these Laboratories. 2,3 We now describe a new, efficient and stereocontrolled route which leads to (t)-perhydrohistrionicotoxin