## Abstract Starting from ethyl 2‐cyclohexen‐1‐carboxylate (**3**) the total synthesis of the perhydrohistrionicotoxin intermediate **23** was achieved in 25% overall‐yield. The two key steps involve a positionally specific addition of HOBr to the oxime‐olefin **7** and the alkylation of bromooxime
✦ LIBER ✦
A new synthetic route to (±)-perhydrohistrionicotoxin
✍ Scribed by E.J. Corey; Martin Petrzilka; Yoichiro Ueda
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 265 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The first total synthesis of (+)-perhydrohistrionicotoxin (I), a useful neurotoxin, 1 was recently reported from these Laboratories. 2,3 We now describe a new, efficient and stereocontrolled route which leads to (t)-perhydrohistrionicotoxin
📜 SIMILAR VOLUMES
A New Synthetic Route to (±)-Perhydrohis
✍
E. J. Corey; Martin Petrzilka; Yoichiro Ueda
📂
Article
📅
1977
🏛
John Wiley and Sons
🌐
German
⚖ 604 KB
A new stereoselective synthetic route to
✍
Toshiro Ibuka; Yoshinori Mitsui; Kenji Hayashi; Hiroyuki Minakata; Yasuo Inubush
📂
Article
📅
1981
🏛
Elsevier Science
🌐
French
⚖ 240 KB
A New Synthetic Route to Aminothiazolino
✍
M. Kidwai; A. D. Mishra
📂
Article
📅
2004
🏛
John Wiley and Sons
⚖ 103 KB
👁 2 views
## Abstract For Abstract see ChemInform Abstract in Full Text.
A new synthetic route to benzodiazepines
✍
James A. Deyrup; J.C. Gill
📂
Article
📅
1973
🏛
Elsevier Science
🌐
French
⚖ 139 KB
A new synthetic route to prostaglandins
✍
E.J Corey; Koichi Niimura; Yoshitaka Konishi; Shinsuke Hashimoto; Yasumasa Hamad
📂
Article
📅
1986
🏛
Elsevier Science
🌐
French
⚖ 272 KB
A new synthetic route to prostaglandins
✍
E.J. Corey; Barry B. Snider
📂
Article
📅
1973
🏛
Elsevier Science
🌐
French
⚖ 171 KB