## Abstract For Abstract see ChemInform Abstract in Full Text.
A new synthetic route to benzodiazepines
β Scribed by James A. Deyrup; J.C. Gill
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- French
- Weight
- 139 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## Abstract Starting from ethyl 2βcyclohexenβ1βcarboxylate (**3**) the total synthesis of the perhydrohistrionicotoxin intermediate **23** was achieved in 25% overallβyield. The two key steps involve a positionally specific addition of HOBr to the oximeβolefin **7** and the alkylation of bromooxime
The first total synthesis of (+)-perhydrohistrionicotoxin (I), a useful neurotoxin, 1 was recently reported from these Laboratories. 2,3 We now describe a new, efficient and stereocontrolled route which leads to (t)-perhydrohistrionicotoxin