A new synthetic route to 7 α-methoxycephalosporins
✍ Scribed by Kunio Atsumi; Kiyoaki Katano; Ken Nishihata; Fumio Kai; Eiichi Akita; Taro Niida
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 261 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Treatment of 7C-(2,2.3-trihaloalkylideneamino)cephalosporins with excess methanol in the presence of acid scavenger gave 7p-(2-haloalk-2-enylideneamino)-7+methoxycephalosporins.
📜 SIMILAR VOLUMES
Since the suggestion by Strominger and Tipper 1) that 6-methyl penicillins and 7-methyl cephalosporins should have enhanced antimicrobial activity, a number of 6 or 7-substituted penicillins or cephalosporins have been synthesized.
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Starting from ethyl 2‐cyclohexen‐1‐carboxylate (**3**) the total synthesis of the perhydrohistrionicotoxin intermediate **23** was achieved in 25% overall‐yield. The two key steps involve a positionally specific addition of HOBr to the oxime‐olefin **7** and the alkylation of bromooxime