## Abstract Nitriles can be obtained in good yields (60β80%) by treatment with oxygen at 30Β° of a methanolic solution of the corresponding aldehyde, containing ammonia, a strong base and a catalytically active copper complex. Yields are lower for baseβsensitive aldehydes. In a similar way, but in
A new synthesis of nitriles
β Scribed by Takahiro Saraie; Toshihiro Ishiguro; ]Kenya Kawashima; Katsura Morita
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- French
- Weight
- 139 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
The dehydration of amides or aldoximes to yield nltriles generally requires Lewis acids and vigorous reaction conditions, which prevent one from applying the method to thermally labile nitriles.
Recently sane efforts have been made to achieve the dehydratlon under milder conditions. For example, amldes and aldoximes were dehydrated
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The r~glion of allylindium reagents with oert;fin nitriles 1 having another el~'tron withdrawing group at the a-position aliiwds the correslxmding allylation-enamination products 2 in high to good yields.