Reductive Cyclization of δ-Hydroxy Nitriles: A New Synthesis of Glycosylamines.
✍ Scribed by Andew D. Dorsey; Jennifer E. Barbarow; Dirk Trauner
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 152 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract New δ‐(polyfluoroalkyl)‐δ‐hydroxy‐α‐amino acids were synthesized from the corresponding starting 3‐(benzoylamino)‐6‐(polyfluoroalkyl)‐2__H__‐pyran‐2‐ones. The key step of the synthesis was the hydrogenation of the pyrone ring. Stereoselectivity and yields depended dramatically on the re
We wish to report an intramolecular cyclisation between nitrile and conjugated diene moieties leading to a monoterpene alkaloid with a pyridine nucleus. Rose bengal-sesitized photooxygenation of (-)-citronellonitrile' (&) in methanol followed by reduction of the
The dehydration of amides or aldoximes to yield nltriles generally requires Lewis acids and vigorous reaction conditions, which prevent one from applying the method to thermally labile nitriles. Recently sane efforts have been made to achieve the dehydratlon under milder conditions. For example, am
## Abstract Nitriles can be obtained in good yields (60‐80%) by treatment with oxygen at 30° of a methanolic solution of the corresponding aldehyde, containing ammonia, a strong base and a catalytically active copper complex. Yields are lower for base‐sensitive aldehydes. In a similar way, but in