## Sunanary: The first synthesis of geiparvarin as well as assignment of configuration of the previously undefined trisubstituted olefinic bond has been achieved.
A new nitrile oxide based synthesis of the antitumor agent geiparvarin
β Scribed by Pier Giovanni Baraldi; Achille Barco; Simonetta Benetti; Mario Guarneri; Stefano Manfredini; Gian Piero Pollini; Daniele Simoni
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 170 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## Abstract The synthesis of a series of 3βImidazolylazole derivatives using cycloaddition reactions of a useful new nitrile oxide is described.
## Abstract The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by Xβray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monoca