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Structure, synthesis, and antitumor activity of the hydrolysis product of the antitumor agent carmethizole

✍ Scribed by Wayne K. Anderson; D. Michael Houston; Mark A. Jarosinski; Frederick R. Kinder Jr.; Rao N. Kode; Patrick Van Roey; Jeffrey M. Salerno

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
338 KB
Volume
30
Category
Article
ISSN
0272-4391

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✦ Synopsis

Abstract

The two isomeric monocarbamates, 2b and 2c, related to the antitumor drug carmethizole (1) were synthesized and the structure of the carmethizole hydrolysis product, 2b, was established by X‐ray crystallography. The chemical reactivity, toxicity, and antitumor activity of the two monocarbamates, 2b and 2c, were compared with 1. Β© 1993 wiley‐Liss, Inc.

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