The synthesis of 4-azaspiro[2.#]heptanecarboxylic acid is described. This new amino acid is an analog of proline with potential application as an inhibitor and mechanistic probe of prolyl 4-hydroxylase.
A new synthesis of armentomycin and its analog
โ Scribed by Yuji Urabe; Tameo Iwasaki; Kazuo Matsumoto; Muneji Miyoshi
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 221 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Treatment of 6,6t-di-O-trityl-trehalose (1) [2] with benzyl chloride in dioxane followed by acid hydrolysis and chromatography gave the chromatographically pure 2,3,4,2~,3~,4\*-hexa-Obenzyl trehalose (2). Compound 2 was converted into the corresponding 6,6'-di-O-methanesulphonyl derivative 3 in quan
Kadsurenone, a specific receptor antagonist of platelet-activating factor and a natural product isolated from Piper futokadsura was prepared in three steps from 3,4-dimethoxycinnamyl alcohol and allyloxyphenol via rac\_(2S,3S)-5-allyl-6-hydroxy-2\_(3,4-dimethoxyphenyl)-3-methyl-2,3-dihydrobenzofuran
Synthesis of Enantiomerically Pure D-and L-Armentomycin and Its Difluoro Analogues from Aspartic Acid. -The biologically active title compound (V) and its difluoro analogue ( VII) are prepared without racemization via the hexafluoroacetone-protected intermediate (III). -