## Abstract Immune response suppressors are used in the medical praxis to prevent graft rejection after organ transplantation and in the therapy of some autoimmune diseases. As a continuation of our previous work searching for new, effective suppressors devoid of toxicity, we present the synthesis,
Synthesis of a new analog of proline
β Scribed by Russell C. Petter
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 286 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The synthesis of 4-azaspiro[2.#]heptanecarboxylic acid is described. This new amino acid is an analog of proline with potential application as an inhibitor and mechanistic probe of prolyl 4-hydroxylase.
π SIMILAR VOLUMES
The asymmetric synthesis of a new proline surrogate, incorporating the dimethylsilyl group at position 4 of proline using SchΓΆllkopf's bis-lactim ether method, is described.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Treatment of 6,6t-di-O-trityl-trehalose (1) [2] with benzyl chloride in dioxane followed by acid hydrolysis and chromatography gave the chromatographically pure 2,3,4,2~,3~,4\*-hexa-Obenzyl trehalose (2). Compound 2 was converted into the corresponding 6,6'-di-O-methanesulphonyl derivative 3 in quan